Sellke Laboratory

    Frank Sellke, MD
    Karlson Professor of Cardiovascular Surgery, Rhode Island Hospital and Brown University

    Dr. Frank W. Sellke, the Karlson and Karlson Professor and the Chief of Cardiothoracic Surgery at the Alpert Medical School of Brown University and Lifespan, is an accomplished clinician, educator and researcher in the cardiovascular field. His research focuses on microcirculation of the heart, lung and other organs as it relates to vasomotor regulation, permeability, collateral development, and inflammation during cardiac surgery. The role of therapeutic angiogenesis and cell therapy for the treatment of inoperable coronary disease is a main focus of his work. He has utilized several clinically relevant pig models of chronic ischemia in diabetes and hypercholesterolemia to examine alterations in cell signaling and growth of collateral vessel formation and myocardial function. He also has an active participation in the search for drugs that can decrease myocardial cell death after ischemia-reperfusion.