Pulmonary hypertension is a disease associated with increased blood pressure in the lung blood vessels.
Pulmonary arterial hypertension is associated with pulmonary vascular remodeling and endothelial dysfunction. Researchers in the division of cardiology have been investigating roles of endothelial ion channels and mitochondrial metabolism in mediating endothelial dysfunction, pulmonary vasoconstriction and pulmonary vascular remodeling as novel therapeutic targets in pulmonary hypertension.
Researchers in the division also investigate how immune system mediates vascular remodeling where macrophages direct the biologic processes of arteriogenesis, vascular calcification, and pulmonary arterial hypertension. Researchers are studying novel macrophage-dependent signaling mechanisms that modulate these processes, using a diverse array of techniques in molecular biology, immunobiology, small animal genetics, and vascular biology.
The research program in the Cardiovascular Research Center and Vascular Research Laboratory also include clinical and translational studies pertaining toright ventricular dysfunction and failure ,the cause of mortality associated with pulmonary hypertension. Researchers in the Cardiovascular Research Center are investigating right ventricular function in clinical cohorts as well as animal models of pulmonary hypertension. Researchers are also investigating the epidemiology of pulmonary hypertension in a community-based population and in the VA cohorts.
⍺7 nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension (https://pubmed.ncbi.nlm.nih.gov/33974567/)
PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension (https://pubmed.ncbi.nlm.nih.gov/25659900/)
Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A (https://pubmed.ncbi.nlm.nih.gov/35108537/)
Right Ventricular Ejection Fraction and Beta-Blocker Effect in Heart Failure With Reduced Ejection Fraction (https://pubmed.ncbi.nlm.nih.gov/34419597/)
Gender Differences in Risk Factors Associated With Pulmonary Artery Systolic Pressure, Heart Failure, and Mortality in Blacks: Jackson Heart Study. (https://pubmed.ncbi.nlm.nih.gov/31902323/)
Dr. Gaurav Choudhary
Dr. Alan R. Morrison
Laboratory: https://cpvb.org/alan-morrison-md-phd/ & https://www.brown.edu/research/labs/vascular/faculty/morrison-lab-overview