Gideon Koren, MD
Professor of Medicine, Cardiovascular Research Center Rhode Island Hospital and Brown University
Email: Gideon_Koren@Brown.edu
Click here for Dr. Koren’s Publications
Dr. Gideon Koren is interested in understanding the pathogenesis of cardiac arrhythmias through three main lines of investigation: 1) Genomic studies to elucidate the transcriptional program(s) that control the expression of membrane polypeptides involved in determining the duration of cardiac action potential and early and late afterdepolarizations, as well as the aging of the heart. As part of these studies Dr. Koren is interested in studying the differentiation and senescence of adult cardiac stem cells; 2) Investigation of the trafficking and localization of voltage-gated potassium channels in the cardiomyocytes; and 3) Creation of genetically modified animal models for studying sudden cardiac death. Dr. Koren’s laboratory is also focusing on the molecular mechanisms underlying the trafficking post translational modifications and turnover of Kv1.5 and KV2.1 potassium channels in the heart and protein interactions between HERG and KCNQ1. His group is characterizing the macromolecular complex (channelosome) that modulates the localization and function of several delayed rectifier potassium channels in the heart. In addition, his laboratory has analyzed and compared the phenotype of two novel transgenic rabbit models of long QT syndrome 1and 2 (LQT1 and LQT2) using surface ECG; monitoring of alert, free-moving rabbits, programmed electrical stimulation (PES) of the right ventricle of anesthetized rabbits, and analyses of the biochemical and electrophysiological phenotype of rabbit cardiomyocytes derived from the epicardial, mid-myocardial, and endocardial layers of the left ventricle.
Laboratory Staff
Brett Baggett, BS
PhD Candidate
Rhode Island Hospital and Brown University
Email: brett_baggett@brown.edu
Peter Bronk, PhD
Research Scientist
Rhode Island Hospital and Brown University
Email: PBronk@Lifespan.org
Anatoli Kabakov, PhD
Assistant Professor
Rhode Island Hospital and Brown University
Email: Anatoli.Kabakov@lifespan.org
Eric Mi
PhD Candidate
Rhode Island Hospital and Brown University
Email: Eric_Mi@Brown.edu
YiChun Lu, MS
Senior Research Assistant
Rhode Island Hospital
Email: YLu@Lifespan.org
Karim Roder, PhD
Assistant Professor
Rhode Island Hospital and Brown University
Email: Karim.Roder@Lifespan.org
Elif Sengun, PhD Student
PhD Student
Rhode Island Hospital and Brown University
Email: Elif_Sengun@Brown.org
Nilufer Turan Dural, PhD
Micro Surgeon
Rhode Island Hospital and Brown University
Email: Nilufertu@gmail.com
