O-Uchi Laboratory

    Jin O-Uchi, MD, PhD
    Assistant Professor of Medicine (Research), Rhode Island Hospital and Brown University
    Email: Jin.Ouchi@Lifespan.org

    Click here for Dr. O-Uchi’s Publications

    Click here for Dr. O-Uchi’s Brown University Website

    Dr. Jin O-Uchi is interested in understanding the molecular mechanisms underlying sudden cardiac death and heart failure (HF) by ion channel disorders, specifically focusing on cellular and mitochondrial calcium (Ca2+)-handling disorders.

    Current projects in the O-Uchi laboratory include investigations of 1) functional significance of adrenergic signaling for the regulation of mitochondrial Ca2+ influx mechanism in the cardiomyocytes; 2) the role of proline-rich tyrosine kinase 2 (Pyk2) in the HF development, especially focusing on the Pyk2-dependent phosphorylation of mitochondrial Ca2+ Uniporter (MCU) and 3) the pathophysiological role of mitochondria-localized ryanodine receptor type 1 (RyR1) in the heart using knock-in mice carrying a RyR1 mutation Y522S (YS mice) found in the human malignant hyperthermia (MH) family. Our central hypothesis is that chronic mitochondrial Ca2+ overload either via hyperphosphorylated MCU or leaky mutant RyR1 in cardiac mitochondria induces mitochondrial injury and cellular oxidative stress, which leads to HF and/or cardiac arrhythmia. His research projects is supported by American Heart Association (AHA) Beginning Grant-in-Aid, AHA Scientist Development Grant, Research Career Enhancement Award, American Physiological Society and Medical Research Grant from the W.W. Smith Charitable Trust.

    Laboratory Staff

    Dongqin Yang
    Senior Research Assistant
    Rhode Island Hospital
    Email: Dongqin.Yang@Lifespan.org

    BongSook Jhun, PhD
    Assistant Professor of Medicine
    Rhode Island Hospital
    Email: bongsook.jhun@lifespan.org